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As a dietary supplement to restore your circadian rhythm and help with sleep, Life Extension advises taking a 50 mg capsule of nobiletin once daily. They advise taking it before bedtime, however their supplement also contains melatonin.
If you’re taking a supplement without melatonin, taking it at dinner is probably a better time.
Nobiletin bioavailability may be best with a meal. This is because research has reported low water solubility and low oral bioavailability. *