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Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.
Isoquercitrin exerts inhibitory effect on Wnt/β-catenin signaling and no toxic effects on colon cancer cell lines. It supresses the proliferation of colon cancer cells but does not affect non-tumoral colon cells. Isoquercitrin inhibits cell migration in colon cancer cells, but has also no apparent effect on the non-tumor colon cells. Isoquercitrin inhibits the signaling downstream of β-catenin nuclear translocation as isoquercitrin reverses the effect of β-catenin S33A, which cannot be phosphorylated and avoids degradation.
Isoquercitrin treatment significantly affects Xenopus embryo development, most likely by disturbing axial patterning. Isoquercitrin affects canonical Wnt signaling downstream of β-Catenin nucleus translocation. In animals receiving isoquercitrin, eosinophil counts are lower in the bronchoalveolar lavage fluid (BALF), blood and lung pa-renchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate are lower in isoquercitrin-treated mice. No alterations in mononuclear cell numbers are observed. Isoquercitrin also demonstrates anti-asthmatic activity by inhibiting of carbachol- and leukotriene D4-induced contraction in guinea pig airways.