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While they’re not commonly a problem for most people, portobello mushrooms contain purines that are linked to health problems in some cases. Purines break down to form uric acid, which can accumulate and lead to conditions like gout or kidney stones and kidney dysfunction. If you struggle with one of these conditions, avoid mushrooms and other sources of purines, or only eat them in moderation.
If you’ve ever had an allergic reaction to other types of mushrooms, it’s best to use caution when eating portobellos, especially since they’re related to other edible mushrooms and can cause similar effects. *