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5000 mg/kg oral intake in rats of the water extract has failed to show any signs of clinical toxicity whereas 28 days ingestion of 1000 mg/kg also failed. Other studies have noted a failure of 2,000 mg/kg of a 70% ethanolic extract and no adverse effects with 1,000 mg/kg of 95% ethanolic extract although injections of Jatamansi 95% ethanolic extract have noted an LD50 value of 569+/-20.8 mg/kg. *