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Possible Side Effects
Little is known about the long-term safety of Pueraria mirifica. Due to the herb's estrogen-like effects, symptoms such as bloating, cramps, breast tenderness, headache, weight changes, and irregular periods are possible.
With that said, none of the above listed studies reported significant side effects, even with up to six months of daily use.
Because of its estrogen-like effects, Pueraria mirifica should not be used during pregnancy or breastfeeding. It should also be avoided in women with estrogen-sensitive conditions, such as breast cancer, ovarian cancer, endometriosis, and uterine fibroids.
A 2016 study in the journal Toxin reported that a 0.3% Pueraria mirifica solution significantly increased the risk of breast and endometrial cancer in female lab rats after 36 weeks.
Pueraria mirifica should be used with caution in people with liver disease since the herbal metabolites are broken down by the liver. Excessive use can place strain on the liver and potentially cause liver damage.
It is unknown if Pueraria mirifica can interact with other drugs. *