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When taken by mouth: Proteolytic enzymes are possibly safe when taken appropriately. Side effects are usually mild or moderate and include stomach and intestinal complaints. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
Pregnancy and breast-feeding: There isn't enough reliable information to know if proteolytic enzymes are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.*