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When taken by mouth: Manganese is LIKELY SAFE for most adults when taken by mouth in amounts up to 11 mg per day. However, people who have trouble getting rid of manganese from the body, such as people with liver disease, may experience side effects when taking less than 11 mg per day. Taking more than 11 mg per day by mouth is POSSIBLY UNSAFE for most adults.
When given by IV: Manganese is LIKELY SAFE when given by IV as part of parenteral nutrition under the supervision of a health care provider. It's generally recommended that parenteral nutrition provides no more than 55 mcg of manganese per day, especially when used long-term. Receiving more than 55 mcg of manganese per day by IV as part of parenteral nutrition is POSSIBLY UNSAFE for most adults.
When inhaled: Manganese is LIKELY UNSAFE when inhaled by adults for long periods of time. Excess manganese in the body can cause serious side effects, including poor bone health and symptoms resembling Parkinson disease, such as shaking (tremors).
Special Precautions & Warnings:
Children: Taking manganese by mouth is
LIKELY SAFE for children 1 to 3 years in amounts less than 2 mg per day; for children 4 to 8 years in amounts less than 3 mg per day; for children 9 to 13 years in amounts less than 6 mg per day; and for children 14 to 18 years in amounts less than 9 mg per day. Manganese in higher doses than described is
POSSIBLY UNSAFE. Talk with your health care provider before giving manganese to children. High doses of manganese might cause serious side effects. Manganese is
LIKELY UNSAFE when inhaled by children.
Pregnancy and breast-feeding: Manganese is
LIKELY SAFE in pregnant or breast-feeding adult women aged 19 or older when taken by mouth in doses of less than 11 mg per day. However, pregnant and lactating women under age 19 should limit doses to less than 9 mg per day. Manganese is
POSSIBLY UNSAFE when taken by mouth in higher doses. Doses over 11 mg per day are more likely to cause serious side effects. Taking too much manganese might also decrease the birth size of male infants. Manganese is
LIKELY UNSAFE when inhaled by women who are pregnant or breast-feeding.
Long-term liver disease: People with long-term liver disease have trouble getting rid of manganese. Manganese can build up in these people and cause shaking, mental problems such as psychosis, and other side effects. If you have liver disease, be careful not to get too much manganese.
Iron-deficiency anemia: People with iron-deficiency anemia seem to absorb more manganese than other people. If you have this condition, be careful not to get too much manganese.
Nutrition that is given intravenously (by IV). People who receive nutrition intravenously (by IV) are at an increased risk of side effects due to manganese.
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