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Treatment with luteolin and other flavonoids temporarily increased irritability in 50% of children with autism spectrum disorders.
In animal and cell studies, luteolin didn’t harm healthy cells or cause significant side effects.
Luteolin blocks the effects of progesterone, which might be detrimental in cases of uterine and cervical cancer. The evidence around its effect on estrogen is contradicting and requires further investigation.
While luteolin prevented spontaneous colitis (colon inflammation) in animals, it worsened chemically-induced colitis. By inhibiting NF-kB, it blocked protective molecules in intestinal cells.
Pregnant women and children should avoid luteolin supplements, unless under strict medical supervision.
Luteolin supplements may have adverse effects for autistic children, people with colitis, and pregnant people. *