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Although supplementing with threonine in appropriate amounts is generally considered safe, some people may experience minor side effects, such as headache, nausea, upset stomach and skin rash.
There is not enough evidence to recommend that women who are pregnant or breastfeeding should take threonine supplements. Instead, it’s best to get enough of the amino acid from a well-balanced diet.
People taking NMDA antagonists called memantine (Namenda), which are a type of medication for Alzheimer’s disease, should avoid using this supplement. The amino acid may reduce how well these medications work. *