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Overall, glutamine seems safe to consume in moderate amounts, especially if taken short term. There seems to be low risk for side effects when taken in doses up to 20 to 30 grams per day, which are considered higher doses but have been used safely in some studies short term.
Although the effects of excess glutamine rarely cause problems, if you take oral glutamine long term, it’s a good idea to also supplement with B vitamins. This especially applies to vitamin B12, which controls glutamine buildup in the body.
Who should not take glutamine?
Anyone with a history of kidney disease, liver disease, Reye’s syndrome or cancer should not take this supplement unless working with a doctor, since these conditions can affect how amino acids are absorbed.
If you’re battling cancer and/or undergoing cancer treatments, always speak with your doctor about which supplements may or may not be helpful.
In rare cases, allergic reactions to this supplement have been reported. Stop taking it right away if you experience symptoms like nausea, vomiting, hives, dizziness or pain. *