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Unfortunately, not enough research has been done on betaine hydrochloride in order to know if it’s safe to use. According to a 2016 report published in Integrative Medicine: A Clinician’s Journal, one potential side effect is heartburn.
If you’re pregnant or breastfeeding, avoid taking betaine HCL since there’s no information on how it may affect you or your baby.
Because betaine HCL can boost the amount of hydrochloric acid in your stomach, it may irritate stomach ulcers or prevent them from getting better. For this reason, it’s best not to take betaine HCL if you have a peptic ulcer or live with peptic ulcer disease. *
