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Escin Interactions
When this drug applied simultaneously with:
- inhibitors increases the risk of serotonin syndrome and serious adverse reactions.
- serotonergic agents (including with tramadol, triptans) may lead to serotonin syndrome.
- drugs to lower the threshold of convulsive readiness, the risk of seizures increases.
Escin increases the effects of tryptophan and lithium drugs, increases the toxicity of preparations based on hypericum, the effects of drugs affecting blood clotting (requires monitoring of indicators of blood coagulation).
Drugs metabolized with the participation of CYP2C19 isoenzyme (including omeprazole), and are potent inhibitors of CYPZA4 and CYP2D6 (including flecainide, propafenone, metoprolol, desipramine, clomipramine, nortriptyline, risperidone, thioridazine, haloperidol), increase concentration of this medication in plasma.
Escin increases the plasma concentrations of desipramine and metoprolol in 2 times.
Escin Side Effects
Erythema. Desquamation. Urticaria and angio-neurotic oedema may occur in aspirin sensitive patients following exposure to local application.
Due to its alcohol content, Escin-Gel should not be applied to areas of eczema or ulceration, nor to skin exposed to therapeutic irradiation, but only to the surrounding parts in order to avoid a possible burning sensation.
Escin Contraindications
Simultaneous administration of MAO inhibitors, childhood and adolescence to 15 years, pregnancy, lactation, hypersensitivity to Escin. *