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When taken by mouth: Artichoke is LIKELY SAFE when taken in amounts used in foods. It is POSSIBLY SAFE when taken as a medicine. It has been used safely in research for up to 12 weeks.
In some people, artichoke can cause side effects such as gas, upset stomach, and diarrhea. Artichoke might also cause allergic reactions. People at the greatest risk of allergic reactions are those who are allergic to plants such as marigolds, daisies, and other similar herbs.
Pregnancy and breast-feeding: There isn't enough reliable information to know if artichoke is safe to use as a medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
Bile duct obstruction: There is concern that artichoke might worsen bile duct obstruction by increasing bile flow. If you have this condition, don't use artichoke without first talking with your healthcare provider.
Allergy to ragweed and related plants: Artichoke may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking artichoke.
Gallstones: Artichoke might make gallstones worse by increasing bile flow. *