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When taken by mouth: Apple polyphenols are POSSIBLY SAFE when taken short-term. Taking apple polyphenols might cause mild gastrointestinal side effects, such as diarrhea.
When applied to the skin: Apple polyphenols are POSSIBLY SAFE when used appropriately.
Insulin interacts with APPLE POLYPHENOLS
Taking apple polyphenols before a meal might cause blood glucose levels to rise more slowly after a meal. Using insulin before a meal also lowers blood glucose levels after a meal. Taking apple polyphenol extract along with insulin might cause your blood sugar to go too low. Monitor your blood sugar closely. The timing of your insulin dose might need to be changed. *