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Most people taking rapamycin for anti-aging seem to have settled on a weekly dose, largely because that was the dosing frequency originally used in the Mannick 2014 Study of the rapalog everolimus. That study used a weekly dose and saw only minor side effects over the period of the study.
Other people are looking at the research on the half-life of rapamycin (typically cited as somewhere between 62 and 80+ hours - and seems to vary by age and ethnicity) and then evaluating their dose and weight and determining when their blood sirolimus levels are at a trough level that they consider safe enough for the next dose. For some people this is 10 or 12 days. As you can see in the graph below tracking blood sirolimus levels over time, there is a quick initial peak about 1 hour after taking the medicine, and then it decreases by about 50% every 65 to 85 hours.
Lately, some people have started taking higher doses (e.g. 20mg) with a once every two weeks dosing schedule. This has been adopted by Dr. Mikhail Blagosklonny because he believes that the higher intial dose may help penetrate the blood brain barrier. *