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Usual Adult Dose for Diabetes Type 2
Immediate-release:
Initial dose: 500 mg orally twice a day or 850 mg orally once a day
-Dose titration: Increase in 500 mg increments weekly or 850 mg every 2 weeks as tolerated
Maintenance dose: 2000 mg/day in divided doses
Maximum dose: 2550 mg/day
Extended-release:
Initial dose: 500 to 1000 mg orally once a day
Dose titration: Increase in 500 mg increments weekly as tolerated
Maximum dose: 2000 mg/day
Switching to Extended-Release:
-Patients receiving immediate-release may switch to extended-release once a day at same total daily dose (up to 2000 mg/day)
Comments:
-Metformin, if not contraindicated, should be considered first line-therapy for the management of type 2 diabetes mellitus.
-Immediate-release: Take in divided doses 2 to 3 times a day with meals; titrate slowly to minimis gastrointestinal side effects. In general, significant responses are not observed with doses less than 1500 mg/day and doses above 2000 mg are generally associated with little additional efficacy and poorer tolerability.
-Extended-release (ER): Take with the evening meal; if glycemic control is not achieved with ER 2000 mg once a day, may consider splitting daily dose to ER 1000 mg twice a day; if glycemic control is still not achieve, consider switch to immediate-release product.
Use: To improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.
Usual Pediatric Dose for Diabetes Type 2
10 years or older:
Immediate-release:
Initial dose: 500 mg orally twice a day
-Dose titration: Increase in 500 mg increments weekly as tolerated; daily dose should be taken in divided doses 2 to 3 times a day with meals
Maximum dose: 2000 mg/day
Extended-release oral suspension:
Initial dose: 500 mg orally once a day with evening meal
-Dose titration: Increase in 500 mg increments weekly based on glycemic control and tolerability
Maximum dose: 2000 mg/day
Comments:
-Titrate slowly to minimize gastrointestinal side effects.
Use: To improve glycemic control in children with type 2 diabetes mellitus as an adjunct to diet and exercise. *