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The following doses have been studied in scientific research:
BY MOUTH:
- For osteoarthritis: 1.5 to 6 grams of MSM daily taken in up to three divided doses for up to 12 weeks has been used. 5 grams of MSM plus 7.2 mg of boswellic acid taken daily for 60 days has been used. A specific product (Artrosulfur C, Laborest Italia S.p.A) containing MSM 5 grams, boswellic acid 7.2 mg, and vitamin C taken daily for 60 days has been used. One capsule of a combination of collagen type II with MSM, cetyl myristoleate, lipase, vitamin C, turmeric, and bromelain (AR7 Joint Complex, Robinson Pharma), taken daily for 12 weeks, has been used. 1.5 grams of MSM taken daily plus 1.5 grams of glucosamine in three divided doses daily for 2 weeks has been used. MSM 500 mg, glucosamine sulfate 1500 mg, and chondroitin sulfate 1200 mg taken daily for 12 weeks has been used. *
Oral supplementation of MSM ranges in dose from 500 milligrams to 3 grams per dose, taken twice daily in most studies. Recommended dosage is partly determined by the intended outcome for this supplement. For example, studies of antioxidant benefits and osteoarthritis therapy related to MSM vary from 1.5-3 grams daily.
For enhanced recovery from soft tissue injuries the dose may be as small as 50 milligrams. Although anecdotal evidence shows dosage could be higher (up to 20 grams per day), the highest reported dose of MSM in the research literature is 6 grams per day in humans. *