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Horse chestnut tends to be taken in the 400-600 mg range, although it seems that the overall dose is less important than the standardization for aescin which should ultimately reach 100-150 mg daily.
Supplementation tends to be divided into two daily doses divided by 12 hours (so, a morning and evening dose at 8 am and 8 pm as an example), which is due to the active components (aescins) requiring about 12 hours to reach baseline concentrations. *
The following dose has been studied in scientific research:
BY MOUTH:
- For poor blood circulation (chronic venous insufficiency): 300 mg of horse chestnut seed extract containing 50 mg of the active ingredient, aescin, twice daily. *
