Untitled Document
The following doses have been studied in scientific research:
BY MOUTH:
- For involuntary weight loss in people with HIV/AIDS: 3 grams HMB in combination with 14 grams each of arginine and glutamine in two divided doses daily.
- For age-related muscle loss (sarcopenia): 220 mL of a specific liquid nutritional supplementation (Ensure Plus Advance, Abbott) twice daily. *
Supplementation of HMB tends to be in the dosage range of 1-3g daily for the purpose of reducing muscle mass losses over time (anti-catabolic). As HMB is said to be 20-fold more potent than leucine for this purpose, it is seen as equivalent to 20-60g of leucine supplementation.
For the purpose of muscle protein synthesis, HMB and leucine are fairly equivalent if not the latter (leucine) being more potent on a gram basis. HMB is not advised for inducing muscle protein synthesis since leucine is likely more effective as well as cheaper.
Supplementation of HMB prior to an exercise session would require the usage of an HMB free acid rather than a calcium salt, and the above dosage range still holds. For this specific purpose, HMB is to be taken 30-45 minutes before a workout. *