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The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For coenzyme Q10 deficiency: 150-2400 mg per day.
- For a group of disorders that most often cause muscle weakness (mitochondrial myopathies): 150-160 mg per day, or 2 mg/kg per day. In some cases, doses may be gradually increased to 3000 mg per day.
- For heart failure and fluid build up in the body (congestive heart failure or CHF): 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years. Also, 2 mg/kg daily for up to one year has been used.
- For nerve pain in people with diabetes (diabetic neuropathy): 400 mg per day for 12 weeks.
- For fibromyalgia: 300 mg daily for about 6 weeks or 200 mg twice daily for 3 months has been used. A combination of 200 mg of coenzyme Q10 (Bio-Quinon Q10, Pharma Nord) plus 200 mg of ginkgo (Bio-Biloba, Pharma Nord) per day for 12 weeks.
- For HIV/AIDS: 100-200 mg per day for over 4 years.
- For tissue damage caused when there is limited blood flow and then blood flow is restored (ischemia-reperfusion injury): 150-300 mg per day in up to three divided doses for 1-2 weeks before surgery.
- For preventing migraine: 100 mg three times per day, 150 mg once per day, or 100mg once per day for 3 months. A dose of 1-3 mg/kg per day for 3 months has also been used.
- For multiple sclerosis (MS): 500 mg twice daily for 3 months.
- For a group of inherited disorders that cause muscle weakness and muscle loss (muscular dystrophy): 100 mg per day for 3 months.
- For heart attack: 120 mg per day in two divided doses for up to one year. A combination of 100 mg of coenzyme Q10 (Bio-Quinon, Pharma Nord) and 100 mcg of selenium (Bio-Selenium, Pharma Nord) per day for up to one year has also been used.
- For Peyronie disease: 300 mg per day for 6 months
CHILDREN
BY MOUTH:
- For coenzyme Q10 deficiency: 60-250 mg per day in up to three divided doses.
- For preventing migraine: 1-3 mg/kg daily for 3 months has been used in patients aged 3-18 years.
- For a group of inherited disorders that cause muscle weakness and muscle loss (muscular dystrophy): 100 mg daily for 3 months in children aged 8-15 years. *
Dosage Recommendations by Health Condition
Though 90–200 mg of CoQ10 per day is typically recommended, needs can vary depending on the person and condition being treated.
Statin Medication Use
Research has shown that supplementing with CoQ10 reduces muscle pain in those taking statin medications. A study in 50 people taking statin medications found that a dose of 100 mg of CoQ10 per day for 30 days effectively reduced statin-related muscle pain in 75% of patients. However, other studies have shown no effect, emphasizing the need for more research on this topic.
For people taking statin medications, the typical dosage recommendation for CoQ10 is 30–200 mg per day.
Heart Disease
Those with heart conditions, such as heart failure and angina, may benefit from taking a CoQ10 supplement. A review of 13 studies in people with heart failure found that 100 mg of CoQ10 per day for 12 weeks improved blood flow from the heart. Plus, supplementing has been shown to reduce the number of hospital visits and the risk of dying from heart-related issues in individuals with heart failure. CoQ10 is also effective in reducing the pain associated with angina, which is chest pain caused by your heart muscle not getting enough oxygen. What’s more, the supplement may reduce heart disease risk factors, such as by lowering “bad” LDL cholesterol.
For people with heart failure or angina, the typical dosage recommendation for CoQ10 is 60–300 mg per day.
Migraine Headaches
When used alone or in combination with other nutrients, such as magnesium and riboflavin, CoQ10 has been shown to improve migraine symptoms. It has also been found to ease headaches by reducing oxidative stress and free radical production, which may otherwise trigger migraines. CoQ10 decreases inflammation in your body and improves mitochondrial function, which helps reduce migraine-associated pain. A three-month study in 45 women demonstrated that those treated with 400 mg of CoQ10 per day experienced significant reductions in the frequency, severity and duration of migraines, compared to a placebo group.
For treating migraines, the typical dosage recommendation for CoQ10 is 300–400 mg per day.
Aging
As mentioned above, CoQ10 levels naturally deplete with age. Thankfully, supplements can raise your levels of CoQ10 and may even improve your overall quality of life. Older adults with higher blood levels of CoQ10 tend to be more physically active and have lower levels of oxidative stress, which may help prevent heart disease and cognitive decline. CoQ10 supplements have been shown to improve muscle strength, vitality and physical performance in older adults.
To counteract the age-related depletion of CoQ10, it’s recommended to take 100–200 mg per day.
Diabetes
Both oxidative stress and mitochondrial dysfunction have been linked to the onset and progression of diabetes and diabetes-related complications. What’s more, those with diabetes may have lower levels of CoQ10, and certain anti-diabetic drugs may further deplete body stores of this important substance. Studies show that supplementing with CoQ10 helps reduce the production of free radicals, which are unstable molecules that can harm your health if their numbers get too high. CoQ10 also helps improve insulin resistance and regulate blood sugar levels in people with diabetes. A 12-week study in 50 people with diabetes found that those who received 100 mg of CoQ10 per day had significant reductions in blood sugar, markers of oxidative stress and insulin resistance, compared to the control group.
Doses of 100–300 mg of CoQ10 per day appear to improve diabetes symptoms.
Infertility
Oxidative damage is one of the main causes of both male and female infertility by negatively affecting sperm and egg quality. For example, oxidative stress can cause damage to sperm DNA, potentially resulting in male infertility or recurrent pregnancy loss. Research has found that dietary antioxidants — including CoQ10 — may help reduce oxidative stress and improve fertility in both men and women.
Supplementing with 200–300 mg per day of CoQ10 has been shown to improve sperm concentration, density and motility in men with infertility. Similarly, these supplements may improve female fertility by stimulating ovarian response and help slow ovarian aging.
CoQ10 doses of 100–600 mg have been shown to help boost fertility.
Exercise Performance
As CoQ10 is involved in the production of energy, it’s a popular supplement amongst athletes and those looking to boost physical performance. CoQ10 supplements help reduce the inflammation associated with heavy exercise and may even speed recovery. A 6-week study in 100 German athletes found that those who supplemented with 300 mg of CoQ10 daily experienced significant improvements in physical performance — measured as power output — compared to a placebo group. CoQ10 has also been shown to reduce fatigue and increase muscle power in non-athletes.
Doses of 300 mg per day appear to be most effective in boosting athletic performance in research studies. *