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A standard dose for the purposes of cardiac health appears to be 500mg of the bark (water extract) taken daily in the morning without food (no evidence exists to suggest that taking it with food is bad or anything). For persons who suffered cardiac trauma (such as Myocardial Infarction), this dose tends to be taken thrice a day every 8 hours
The leaf extracts and ethanolic extracts appear to be more related to the cytotoxic and anti-tumor effects, but not enough evidence exists to recommend an active dose of these extracts for human consumption. *