Abstract
Objective:
On May 13th, 2020, the Italian government Pharmaceutical Agency (AIFA) stopped Ulipristal Acetate (UPA) treatments for uterine fibroids (UFs), so patients shifted to other natural treatments. Authors tested the patients' compliance to UFs natural treatments.
Methods:
30 patients affected by uterine fibroids in reproductive age (30 - 45 years' old) stopped UPA intake and started Epigallocatechin Gallate (EGCG) plus Vitamin D3 treatment. Patients were asked to complete the Uterine Fibroid symptoms and Quality of Life (UFS-QOL) questionnaire, divided in symptoms severity (SS) and health related QoL (HRQL), after UPA suspension and to repeat it after three months of natural treatment. Collected data were analyzed via paired Student's t Test, considering significant a p value <0.05.
Results:
The SS score was significantly lower (-12.19%) for natural treatment when compared to UPA administration. The health related QoL score resulted significantly improved (+11.79%) after shifting treatment from UPA to natural therapy. All the investigated parameters appeared improved of 10% after the natural treatment. No side effects were reported following the natural treatment.
Conclusion:
Natural treatments showed a positive compliance in patients suffering of UFs, basing on QoL score, representing an alternative therapeutic opportunity for patients forced to stop UPA administration.
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