Abstract
Scope:
Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a chronic recurrent inflammatory disease of the digestive tract and increases the risk of colon cancer.
Method and results:
In this study, we evaluated the effects of dietary intervention with freeze-dried plum (FDP), a natural antioxidant and anti-inflammatory fruit with no toxicity on dextran sulfate sodium (DSS)-induced acute and chronic experimental colitis in a mouse model and studied the molecular mechanisms of protection through the gut-liver axis. The results showed that FDP decreased the levels of inflammatory mediators and, which is a nitrative stress biomarker in both acute and chronic models. FDP markedly reduced DSS-induced injury to the colonic epithelium in both acute and chronic models. In addition, FDP significantly decreased the levels of pro-oxidant markers such as CYP2E1, iNOS, and nitrated proteins (detected by anti-3-NT antibody) in DSS-induced acute and chronic colonic injury models. Furthermore, FDP markedly reduced markers of liver injury such as serum ALT/AST, antioxidant markers, and inflammatory mediators in DSS-induced acute and chronic colonic injury.
Conclusion:
These results demonstrate that the FDP exhibits a protective effect on DSS-induced acute and chronic colonic and liver injury through the gut-liver axis via antioxidant and anti-inflammatory properties. This article is protected by copyright. All rights reserved.
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