Abstract
Abnormal iron accumulation in vital organs is one of the major complications of β-thalassemia intermedia (β-TI). Silymarin, a flavonolignan isolated from Silybum marianum, significantly decreases the serum ferritin levels of β-TI patients. This finding suggests silymarin as a safe and effective natural iron-chelating agent for the treatment of iron-overloaded conditions.
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