Abstract
Background:
Photoaging is closely related to UV-induced oxidative stress. Ferulic acid is a plant-based antioxidant with anti-aging activity. Combining ferulic acid peel with microneedling enhances it's transdermal penetration. This study was designed to evaluate the efficacy of 14% ferulic acid peel combined with microneedling for facial photoaging.
Materials and methods:
16 women aged 45-60 with Fitzpatrick skin type II and III, were enrolled in this trial. All patients received 8 treatment sessions with a full face application of chemical peeling based on 14% ferulic acid in 1-week intervals. During each session, on the right half of patient's face, peeling application was followed by microneedling. Efficacy was measured using MPA (Courage+Khazaka electronic). The measurement of hydration, elasticity, melanin index and erythema index were taken before treatments, after 8th session and 1 month after the last application.
Results:
The objective evaluation showed statistically significant improvement in all measured skin parameters (p<0,05), after ferulic acid peel application, as well as ferulic acid peel followed by microneedling. Combined therapy showed significantly greater improvement especially in skin elasticity, comparing to peeling administered alone.
Conclusion:
Ferulic acid has a significant bleaching, anti-redness, smoothing and moisturizing activity. When combined with microneedling, the efficiency is increased, in particular regarding skin elasticity. This article is protected by copyright. All rights reserved.
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