Abstract
Mango (Mangifera indica L.) kernels are usually discarded as waste, but they contain many pharmacological properties and bioactivities. In this study, we isolated anti-obesity agents from mango kernels that inhibit intracellular lipid formation in 3T3-L1 adipocytes. Two phenolic acids, ethyl gallate and ethyl digallate, and two tannin acids, 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) and 3-O-digalloyl-1,2,4,6-tetra-O-β-D-glucose (HGG), were identified from mango kernels, and were found to be suppressed lipid accumulation as evidenced by Oil Red O staining. Furthermore, ethyl digallate, PGG, and HGG significantly downregulated the mRNA expression of adipogenic transcription factors such as C/EBPα and PPARγ. However, ethyl gallate did not affect the expression of these transcription factors. Our findings reveal the presence of anti-obesity compounds in mango kernels, implying its therapeutic role against obesity.
Full text
