Abstract
Background/aim:
We investigated the anti-proliferative effect of quercetin on liver cancer cell lines.
Materials and methods:
Thirteen liver cancer cell lines were cultured followed by treatment with varying concentrations of quercetin (0-100 μM) or quercetin and 5-FU, and the cell viability was analysed by the MTT assay. Flow cytometry was also used to examine cell cycle progression after treatment with quercetin.
Results:
The addition of quercetin resulted in a dose- and time-dependent suppression of cell proliferation. In some cell lines, treatment with quercetin and 5-FU caused an additional or synergistic effect. Most cell lines displayed cell cycle arrest at different phases of the cell cycle.
Conclusion:
Quercetin inhibits the proliferation of liver cancer cells via induction of apoptosis and cell cycle arrest.
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