Abstract
Background:
Blueberry extract (BE) is rich in phenols, especially anthocyanins. Anthocyanins regulate inflammation response in mice and may be related to gut microbiota and bile acid receptors. The aim of the present study was to explore the effects of blueberry extract (BE) on inflammation response by regulating gut microbiota and bile acid receptors in mice administered with Escherichia coli lipopolysaccharide (LPS).
Method:
Thirty male KM mice were randomly divided into three groups: control diet (CON) group, LPS (LPS stimulation) group, LPS+BE (LPS stimulation, 5% BE intervention) group.
Results:
our results showed that compared with LPS group, the addition of BE decreased the level of inflammatory factors in serum and tissues, inhibited TLR4/MyD88 signaling pathway, protected intestinal barrier, and activated FXR/TGR5, which was related to gut microbiota (especially Akkermansia). The active component (e.g., cyanidin 3-O-glucoside, C3G) in BE may be an important factor in regulating gut microbiota.
Conclusion:
BE alleviated inflammation response mainly by activating bile acid receptor expression and regulating the gut microbiota, and this effect may be related to the composition of bioactive substances in BE. This article is protected by copyright. All rights reserved.
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