Abstract
Background and Objective: Paracetamol does not cause toxic effects if given in therapeutic doses, namely below 4 g per day. Use of paracetamol at a dose of more than 4 g per day can result in hepatotoxicity. This study aims to compare the hepatoprotector potency of the ethanol extract of soursop stem bark (A. muricata) against the enzyme activity of SGOT and SGPT in rats induced by toxic doses of paracetamol. Materials and Methods: A Completely Randomized Design (CRD) comprised of 6 treatment groups and 3 replications. Total 27 white male rats were induced hepatotoxicity with 1350 mg of paracetamol on the 7th day, except for normal control (K0) which was given aquadest. The tested animals received akuades as the negative control (K-) 11.34 mg kg1 b.wt., of Hepa-Q as the positive control (K+), ethanol extract stem bark Annona muricata at a dose of 150 mg kg1 BB (P1), 300 mg kg1 BB (P2) and 600 mg kg1 BB (P3). Results: There was a significant difference (p<0.05) in the levels of SGOT and SGPT after giving ethanol extract of soursop (A. muricata) stem bark. The best treatment for reducing SGOT and SGPT levels in rats induced by paracetamol was the administration of ethanol extract of A. muricata stem bark at a dose of 600 mg kg1 BB. Conclusion: Based on the results of the study, it was concluded that all ethanol extract of Annona muricata L. stem bark (EEAMSB) doses had the potential to reduce the levels of AST and ALT in paracetamol-induced rats.
