PubMed article abstract display

Abstract

Purpose: It is hypothesized that vitamin B₁₂ may prevent tumor initiation during the early stage of carcinogenesis such as esophageal precancerous lesions (EPL), whereas an excessive level may promote tumor progression during the later stages of carcinogenesis. This study aimed to determine the role of vitamin B₁₂ in EPL by detecting vitamin B₁₂-related markers in both blood and diet.

Methods: This case-control study based on 3-day duplicated diet samples was conducted in a high-risk area of Huai'an, China. A 100 EPL cases and 100 healthy controls matched by gender, age (± 2 years) and villages were included. Dietary intake of vitamin B₁₂ and cobalt, plasma cobalt level, the serum levels of vitamin B₁₂ and transcobalamin II (TC II) were quantitatively analyzed.

Results: Dietary vitamin B₁₂ intake (p for trend = 0.384) and plasma cobalt level (p for trend = 0.253) were not associated with EPL risk, but high dietary cobalt intake (p for trend = 0.034), increased serum levels of vitamin B₁₂ (p for trend = 0.036) and TC II (p for trend < 0.001) were significantly associated with the reduced EPL risk. However, the significant negative association between dietary cobalt intake, plasma cobalt level or serum vitamin B₁₂ level and EPL was only found in female or male subjects.

Conclusion: Excellent transport capability of bio-active vitamin B₁₂ in vivo and adequate levels of vitamin B₁₂ and cobalt may play preventive roles in EPL. Additionally, the association between vitamin B₁₂, cobalt and the risk of EPL may vary in different genders.

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