Abstract
Aims:
To assess the association between vitamin D and diabetic foot (DF) in patients with type 2 diabetes mellitus (T2DM), in order to summarize clinical evidence in the prevention and treatment of DF.
Materials and methods:
Between January 2012 and December 2019, a total of 1721 hospitalized patients with T2DM were continuously enrolled in West China Hospital, Sichuan University, which were divided into DF and non-DF groups according to whether with DF, and divided into four subgroups according to admission season. We compared 25-OH-Vitamin D levels between groups and subgroups, and discussed independent risk factors for the occurrence of DF.
Results:
The vitamin D insufficiency and deficiency rate were higher in the DF group (77.51%) than in the non-DF group (59.2%). The 25-OH-Vitamin D levels were lower in the DF group (35.80 nmol/L) than in the non-DF group (45.48 nmol/l) (P<0.001). Patients with poor glycemic control had lower 25-OH-Vitamin D levels (P=0.01). The 25-OH-Vitamin D levels were lower in winter and spring. In the same season, the 25-OH-Vitamin D levels of patients with DF were still lower (P<0.001). The 25-OH-Vitamin D levels of patients with Wagner grades to 5 showed a downward trend(P=0.114). The 25-OH-Vitamin D was independently associated with the DF (P<0.001, OR=0.986).
Conclusions:
The low serum vitamin D level was significantly associated with a higher prevalence of DF among Chinese T2DM patients. Although vitamin D levels vary seasonally, patients with DF were always at higher risk of bearing vitamin D insufficiency and deficiency.
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