Abstract
Background:
Diabetic peripheral neuropathy (DPN) is a prevalent complication of type 2 diabetes mellitus (T2DM). A comprehensive understanding of DPN's causal factors is pivotal for effective prevention and treatment, but the precise clinical pathogenesis remains unclear.
Objective:
To investigate the correlation between blood selenium (Se) levels and DPN in T2DM patients and analyze factors contributing to lesion development.
Methods:
We selected 51 patients with DPN and 57 with T2DM alone between June 2021 and August 2022. Blood glucose, lipid, and Se levels were assessed. Electromyographic evoked potentials measured motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) in DPN patients.
Results:
DPN patients exhibited lower Se, MNCV, and SNCV compared to DM patients, with higher glucose and lipid levels (P < .05). Logistic regression analysis identified age (95%CI 1.256-9.631), disease duration (95%CI 2.160-11.816), fasting blood glucose (95%CI 2.160-11.816), and HbA1c (95%CI 1.064-7.632) as independent risk factors for DPN in T2DM, while Se (95%CI 0.324-1.126) emerged as an independent protective factor (P < .05).
Conclusions:
Blood selenium levels and DPN are closely related, with selenium emerging as a significant factor in DPN occurrence among T2DM patients.
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