Abstract
Dietary habits have major implications as causes of death globally, particularly in terms of cardiovascular disease, cancer and diabetes, but to precisely define the role of the single components of diet in terms of cardiovascular risk is not an easy task, since current epidemiological cohorts do not include sufficient information regarding all the confounding factors typical of nutritional associations. As an example, complex and multifactorial are the possible nutritional or detrimental effects of dietary fats, due to the huge variety of lipid metabolites originating from either the enzymatic or non-enzymatic oxidation of polyunsaturated fatty acids, cholesterol and phospholipids. The area of research that has allowed the benefit/risk profile of a dietary supplement to be tested with controlled studies is that of omega-3 fatty acids. Omega-3 fatty acids have showed a potential therapeutic role only in secondary cardiovascular prevention, while controlled studies in primary prevention have consistently produced neutral results. Despite some favorable evidence in patients with chronic heart failure; a treatment with n-3 PUFA in this clinical context is presently overlooked. The potential risk of atrial fibrillation, especially when n-3 PUFA are used in high doses, is still under scrutiny.
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