Abstract
ObjectiveMagnesium has been implicated in regulating blood pressure and vascular endothelial cell function, but its role in the pathophysiology of intracranial aneurysm is not known. Here we performed a Mendelian randomization analysis to investigate the association between serum magnesium concentration and risk of intracranial aneurysm.MethodsFive single-nucleotide polymorphisms strongly associated with serum magnesium concentrations in a genome-wide association study in 23 829 individuals of European ancestry were used as genetic instruments. Genetic association estimates for intracranial aneurysm were obtained from a genome-wide association study in 79 429 individuals (7495 cases and 71 934 controls). The inverse-variance weighted method was used in the primary analyses to obtain the causal estimates.ResultsHigher genetically predicted serum magnesium concentrations were associated with lower risk of intracranial aneurysm. The odds ratios per 0.1 mmol/L increment in genetically predicted serum magnesium concentrations were 0.66 (95% confidence interval: 0.49-0.91) for intracranial aneurysm (unruptured and ruptured combined), 0.57 (95% confidence interval: 0.30-1.06) for unruptured intracranial aneurysm, and 0.67 (95% confidence interval: 0.48-0.92) for aneurysmal subarachnoid hemorrhage.ConclusionThis study provides evidence to support that increased serum magnesium concentrations reduce the risk of intracranial aneurysm and associated hemorrhage.
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