Abstract
Aims:
The study aimed to study the antihypertensive activity of Laurus nobilis.
Background:
Laurus nobilis L. is used to treat hypertension in Morocco.
Objective:
The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.
Materials and methods:
The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated and the ex-vivo vasorelaxant activity of this extract was performed.
Results:
A considerable decrease of blood pressure parameters was observed in L-NAME-induced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on aorta precontracted with epinephrine or KCl through inhibition of extracellular Ca2+ entry.
Conclusion:
The study demonstrates that Laurus nobilis aqueous extract exhibits a potent antihypertensive and vasorelaxant activities via the inhibition of Ca2+ entry.
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