Abstract
Taxifolin (dihydroquercetin), is a flavanonol isolated from various plants and has antioxidant effect. The aim of our study is to macroscopically and biochemically investigate the effect of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate this effect by comparing taxifolin with famotidine. Rats were divided into four drug administration groups: a healthy control group (HCG), an aspirin-alone group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). In conclusion, in light of the results that we obtained, 50 mg/kg taxifolin was revealed to have anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.
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